By Lou Aguila (staff@latinospost.com) | First Posted: May 18, 2013 07:19 PM EDT

Former pound-for-pound champion Sugar Shane Mosley is ready to lock horns with hard-hitting Pablo Cesar Cano in what will be a make-or-break fight of his career on Saturday, 9 pm.. ET, at the Grand Oasis Resort, Cancun, Quintana Roo, Mexico.

Mosley will make his return in the ring a year after losing to WBC Light Middleweight title holder Canelo Saul Alvarez via unanimous decision on May 5, 2012 at MGM Grand Hotel in Las Vegas.

Mosley retired after his loss to Canelo Alvarez but eventually came out of retirement for another shot at a world title.

Fighting the former three-division champion is Cesar Cano, who's coming off of a heartbreaking split decision loss to Paulie Malignaggi in their WBA Welterweight Clash last October. Despite the loss, Cano looked like a full-fledge middleweight and was able to floor Malignaggi in that fight.

Cano tipped the scale at 146 pounds while Mosley, who once ruled the light middleweight division during his prime, weighed at 146.8 pounds.

Saturday's fight could potentially be disastrous not only to Sugar Shane's boxing career but to his health after absorbing a brutal beating at the hands of Alvarez last year.

Cano, who boasts 26-2-1 record with 20 knockouts, is winless in his last two fights but he looks stronger fighting at a higher weight level.

On the other hand, Mosley hasn't tasted a victory in his last four fights as he fell to Floyd Mayweather Jr., Manny Pacquiao, and Alvarez. Mosley also fought to a highly-disputed split draw with Sergio Mora in 2010.

Mosley won titles in the lightweight, welterweight, and light middleweight division and was once regarded the best boxer on the planet in the early 2000s.

The winner of the Mosley-Cano showdown will claim the vacant WBC international light middleweight title along with a shot at fighting either Canelo Alvarez or IBF champ Ishe Smith.